当前位置:首页 > LXR激动剂调节小鼠巨噬细胞脂质内稳态及其炎症因子分泌的实验研究 - 图文
第三军医大学硕士学位论文照片l正常培养的对数生长期RAW264.7细胞(×200)照片2正常培养的对数生长期RAW264.7细胞(×400)第三军医大学硕士学位论文照片3LXR激动剂对RAW264.7细胞ABCAl蛋白表达的影响(SP法,苏木素复染,×200)(1)对照组(2)MHEC组(3)MHEC+9一eRA组(4)T-1317组(5)T-1317+9一cRA组36第三军医大学硕士学位论文照片4激光共聚焦显微镜观察摄取Dil—Ac.LDL的RAW264.7细胞照片5一步法超速离心分离人血浆脂蛋白由上至下分别为极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及无脂蛋白血清(LPDS)第三军医大学硕士学位论文参考文献1.GlassCK,Witztum儿.Atherosclerosis.Theroadahead.【J]CellAJ.StatinsInhibitSynthesisofan2001,104:503—516.2.WongJ;QuinnCM,BrownOxysterolLigandfortheLiverXReceptorinHumanMacrophagesArteriosclerosis.Thrombosis&VascularWithConsequencesforCholesterolFlux.fJ】.Biology.2004.24(12):2365—2371.understandingofthemetabolism3.vonEckardsteinA,HersbergerM,RohrerL.CurrentandbiologicalactionsofHDL.[J】.CurrentOpinioninClinicalNutrition&MetabolicCare.2005,8(2):147—152.4.MeyersCD,KashyapML.Pharmacologicelevationofhigh—densitylipoproteins:recentinslghtsonmechanismofactionandatherosclerosisprotection.[J1.CurrentOpinioninCardiology.2004,19(4):366—373.5.TontonozP’MangelsdorfDJ.LiverXreceptorsignalingpathwaysincardiovasculardisease.【J】.MolEndocrin01.2003,17:985?993.6.RepaJJ,MangelsdorfDJ.TheliverXreceptorgeneteam:potentialnewplayersinatherosclerosis.NatureMed.2002.8:1243?1248.7.RepaJJ,MangelsdorfDJ.Theroleoforphannuclearreceptorsintheregulationofcholesterolhomeostasis.【J】.Annu.Rev.CellKtLDev.Bi01.2000,16:459—481.8.AlbertiS,SteffensenGustafssonJA.StructuralcharacterizationofthemousenuclearoxysterolreceptorgenesLXRalphaandLXRbeta.【J】.Gene.2000,243:93-103.a9.WillyPJ,UmesonoK,OngES,eta1.LXR,anuclearreceptorthatdefinesdistinctretinoidresponse1pathway.【J】GenesDev.1995,9:1033—1045.a1.ExpressionoftheLXR0.Watanabe,Yuichiro;Jiang,Shuying;Takabe,Wakako;etfalpha】ProteinVascularinHumanAtheroscleroticLesions.[J].Arteriosclerosis,Thrombosis&Biology.2005,25(3):622—627.RA,KokontisJM,eta1.Ubiquitousreceptor:structures,11.SongC,Hiipakkaimmunocytochemicallocalization,andmodulmionofgeneactivationbyreceptorsforretinoicacidsandthyroidhormones.【J].Ann.N.YAcad.Sci.1995,761:38—49.12.JanowskiBA,WillyPJ,DeviTR,eta1.AnoxysterolsignallingpathwaymediatedbythenuclearreceptorLXRalpha.【J】Nature1996,383:728—731.13.EdwardsPA,KastHR,AinsfieldAM.BAREingitall:theadoptionofLXRandFXRand1R
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