年产300吨庆大霉素发酵车间的工艺设计课程设计任务

目 录

设计任务书

1.设计依据及设计原则·······················································1

1.1设计依据································································1

1.1.1 主要文件···························································1 1.1.2 主要技术资料·······················································1 1.2设计原则································································3

2.产品方案··································································3

2.1 产品规格·······························································3 2.2产品主要物性····························································4 2.3 分析方法·······························································4

3.生产方法及工艺流程·······················································4

3.1生产方法································································4 3.2工艺过程································································5 3.2.1工艺流程框图·······················································5 3.2.2工艺流程说明·······················································5 3.3设备框图································································6 3.4 生产特点·······························································7 3.5 工艺介质的腐蚀性·······················································7 3.6带控制点的工艺流程图····················································7

4.原料及中间产品的技术规格················································8 5．物料衡算··································································9

5.1主要物性参数····························································9 5.2物料衡算································································9 5.2.1公称体积与台数的计算···············································9 5.2.2物料衡算··························································10 5.3物料衡算框图···························································11

6.能量衡算·································································11 7.设备计算及选型原则······················································13

7.1设备衡算·······························································13

7.1.1大罐······························································13 7.1.2中罐······························································14 7.1.3小罐······························································15 7.2设备选型的原则·························································16

8.车间布置·································································16

8.1车间的生产性质·························································16 8.2 车间布置说明··························································16 8.2.1 生产工艺·························································16 8.2.2设备安装检修······················································16 8.2.3安全技术··························································16 8.3设备安装要求···························································17 8.3.1情况介绍··························································17 8.3.2安装方案··························································17

9.生产制度和车间定员······················································17

9.1生产制度·······························································17 9.2岗位操作时间表和班组安排···············································17 9.3车间定员表·····························································17

10.设备·····································································18

10.1车间设备概况··························································18

10.1.1种子制备设备····················································18 10.1.2种子罐··························································18 10.1.3发酵罐··························································18 10.2车间设备材料的选择原则················································18 10.3关键设备······························································18

11.仪表及控制······························································18

11.1生产过程特点概述······················································18 11.2工艺参数控制要求······················································18 11.3仪表及自控方案························································19

12.电气·····································································19

12.1车间用电情况··························································19 12.2车间用电要求··························································19

13.给排水··································································19

13.1生产用水情况概述······················································19 13.2生产用水要求··························································19 13.3排水系统的划分························································20

14．暖通·····································································20

14.1生产特点及工作环境的说明··············································20 14.2车间暖通要求··························································20

15.消防·····································································20

15.1发酵车间生产特性概述··················································20 15.2发酵车间消防要求······················································20

16.车间维修································································21 17.环境保护································································21

17.1生产过程中三废排放情况················································21 17.2处理方案······························································21

18.工业卫生及安全防护····················································21

18.1生产特点······························································21 18.2工业卫生及安全防护要求················································21

19.节能·····································································21

19.1能耗分析······························································21 19.2节能措施······························································22

20.设计总结································································22 21.参考文献································································22

任 务 书

课题：年产300吨庆大霉素发酵车间的工艺设计

一、课题的目的、意义：

1、通过该课程的学习将化工原理、工程制图、药剂学、制药工程等方面的知识有机地联系在一起并用于实际生产设计中，巩固已学的知识。

2、掌握制药工程设计的任务、步骤和方法，完成制药工程中某单元反应或局部车间的初步设计，为以后的毕业设计打下基础。

3、通过模拟工程设计，了解工程设计的一般过程，学会收集数据、查找手册、工艺计算、罐体设计以及车间设计平面图设计，掌握工程设计中物料衡算、能量衡算，设备计算等计算。

二、制药工程课程设计的内容和要求：

课程设计是制药工程课程中综合性和实践性较强的环节，要求学生能利用本课程与前修课程的基础知识，了解工程设计的基本内容，掌握药厂设计的基本步骤和方法，培养学生综合应用知识解决实际问题的能力，培养学生工程实际理念和严谨的科学作风。本课程包含课程涉及的基础知识，包括工艺设计说明书、工艺路线的选择、物料衡算或能量衡算或主体设备设计计算及选型等，并绘制带控制点工艺流程图或车间平面布置图或主体设备图。

三、设计说明书及图纸要求：

1、设计工作量要求：

应按设计工作安排圆满完成设计任务，完成一张A1设计图纸，编写课程设计说明书； 2、说明书及图纸质量要求：

设计说明书应包括设计任务书、工艺路线的选择、物料衡算或能量衡算或主体设备计算及选型等，参考文献等相关内容，做到条理清楚，论据充分，计算详实。 图纸要求布局合理，线条清晰，粗实分明，图例图标符合设计规范。

年产300吨庆大霉素发酵车间的工艺设计

1.设计依据及设计原则

1.1设计依据

1.1.1 主要文件:设计任务书

1.1.2 主要技术资料 1、设计技术指标

本设计主要以相关的发酵技术工艺、培养基配方、工艺流程等过程为基础和参考，来进行对年产300吨庆大霉素工程发酵车间工艺的设计。主要设计的参考参数如下： （1）、发酵系统（产量300吨/年）

发酵单位：1400(u/ml） 成品单位：600（u/mg） 发酵周期：136（h） 发酵热：5500 (kcal/m3h ) 装料系数：75%（发酵罐） 65%（一级种子罐） 70%（二级种子罐）

总收率：70% 染菌率：3%

年工作日：330（天） 发酵液粘度：50（CP） 发酵液重度：1050（kg/m3） （2）、无菌空气处理系统

空气处理量：550（m3 / min） 空压机出口压力：0.25~0.3（Mpa） 进罐空气温度：40~45℃ 进总过滤器的相对湿度：60% 空气洁净度：100级 （3）、连续灭菌系统

培养基灭菌处理量：20（m3/h） 连消灭菌温度：135℃ （4）、后处理车间

提取总收率：70%计算。 2、培养基配比

主要原料：黄豆饼粉，淀粉，葡萄糖；

主要辅料：氯化钠，硝酸钠，酵母粉，碳酸钙，蛋白胨，淀粉酶，消沫油等。

培养基配比 原料名称 一级种子罐 培养基配比% 黄豆饼粉 葡萄糖 淀粉 氯化钠 氯化钴 硝酸钠 酵母粉 碳酸钙 蛋白胨 硫酸亚铁 磷酸二氢钾 淀粉酶（kg） 3.0 0.5 2.5 0.4 0.1 0.1 0.6 0.005 二级种子罐 培养基配比% 2.5 0.5 2.5 0.36 0.1 0.1 0.4 0.1%淀粉量 发酵罐 培养基配比% 3.5 6.0 0.001 0.4 2.0 0.0075 0.1%淀粉量 全料 培养基配比% 3.5 6.5 0.001 0.4 1.5 稀料 培养基配比% 2.5 0.5 3.0 0.4 0.1 0.4 0.1%淀粉量