甘磷酸胆碱α-GPC(28319-77-9)

产品说明书产品名称：甘油磷脂酰胆碱；甘磷酸胆碱中文别名：L-Α甘油磷酸(酰)胆碱;甘油磷酰胆碱;SN-甘油基-3-胆碱磷酸；英文名称：L-A-glycerophosphorylcholine；CholineAlfoscerateCAS号：28319-77-9分子式：C8H20NO6P分子量：257.22分子结构：外观：类白色至白色粉末，或粘稠状液体含量：99%，85%包装：25公斤/桶用途：甘油磷酸胆碱(Glycerophosphatidylcholine,GPC)，是机体内磷脂代谢的产物之一，也是重要的神经传递介质乙酰胆碱(Acetylcholine)的生物合成前体。在植物中甘油磷酸胆碱的分布较少。纯净的GPC呈白色粉末状，极性较强，能溶于水、甲醇、乙醇等极性溶剂，不溶于乙酸乙酯、正己烷。在体内，GPC最重要的生理功能在于穿过血脑屏障，为乙酰胆碱和磷脂酰胆碱(PC)的生物合成提供必要的胆碱。乙酰胆碱是中枢神经系统中重要的神经传递介质，帮助脑部完成学习、记忆和认知活动，且能控制浅睡眠和肌动活动。一项公开的临床实验，通过2044个样本研究，表明GPC的服食有助于治疗Alzheimer'sdisease等痴呆症。意大利研究人员发现GPC具有刺激生长激素分泌因子分泌的能力，从而促进机体生长。此外，直接服用GPC，能够促进脑部磷酸肌醇的形成，并提高脑部磷脂的合成数量，为中枢神经系统内的信号传递提供更多地磷脂化合物。增加体内磷脂酰胆碱的合成数量，有助于抵抗年龄增长而引起的细胞膜受损和末梢神经功能的衰退，良好的乙酰胆碱和磷脂水平有助于脑血管的健康。2010年6月国家食品药品监督管理局确定甘油磷酸胆碱可以使用在化妆品中。药品制剂介绍：L-甘磷酸胆碱已经由LPB公司（Novartis/Italfarmaco）开发成为一种促智能药。该药物对衰老性记忆力减退有效。它是作为大脑皮层神经元中乙酰胆碱和神经元膜中磷脂的前体物质而起作用。该药品在意大利（1990年）由LPB公司上市，商品名为Delecit。在意大利，同时还由Novartis公司和Italfarmaco公司经销，商品名分别为Brezal和Gliatilin。在波兰该药品由Italfarmaco公司上市（1993年），商品名为Gliatilin；在阿根廷由Montpellier公司上市（1995年），商品名为Gliatilin；在韩国由DongWha公司上市（1996年，商品名为Gliatilin）；在俄罗斯的上市公司则是Italfarmaco公司（1997年）。在智利和巴西该产品的许可权分别转让给了Silesia公司和Eurofarma公司。在德国该产品也已经获得注册。适应症脑内神经组织退化综合症或者继发性大脑供血不足，具体表现为原生性认知障碍或者老年继发性特性的记忆缺损、定向力混乱和消失、主动性和积极性下降以及注意力无法集中，也包括老年情绪和行为反常，譬如：情绪不稳定，易怒，对周围环境变化反应冷淡，老年假性抑郁症。还可用于保肝、镇吐。小刁

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Productname:Cholineglycerophosphate,CholineAlfoscerateOthername:AlphaGPC,L-ALPHA-Glycerophosphorylcholine;CholineGlycerophosphate;(2S)-2,3-dihydroxypropyl2-(trimethylammonio)ethylphosphate;(2R)-2,3-dihydroxypropyl2-(trimethylammonio)ethylphosphate.CAS:28319-77-9Formula:C8H20NO6PMol.Mass:257.22Mol.structure:Appearance:off-whitetowhitecrystallinepowderorcolorlessstickyliquid.Assay:99%or85%Package:25kg/drumStudieshaveinvestigateditsefficacyforcognitivedisordersincludingstrokeandAlzheimer’sDisease.AnItalianmulticentreclinicaltrialon2,044patientssufferingfromrecentstrokeweresuppliedalpha-GPCindosesof1,000mg/dayfor28daysand400mgthreetimesperdayforthefiveensuingmonths.Thetrialconfirmedthetherapeuticroleofalpha-GPConthecognitiverecoveryofpatientsbasedonfourmeasurementscales,threeofwhichreachedstatisticalsignificance.ForeignNames?Cholinialfosceras(Latin)?Cholinalfoscerat(German)?Alfosceratedecholine(French)?Alfosceratodecolina(Spanish)GenericNames?CholineGlycerophosphate(IS)?Glicerofosfatodecolina(IS)?Glycerophosphatedecholine(IS)?GPCL-α(IS)?L-alpha-Glycerylphosphorylcholine(IS)?α-GPC(IS)BrandNames?AfloscerinDaeWon,SouthKorea?AlfoatirinYuhan,SouthKorea?AlpocoChongKunDang,SouthKorea?AlzheilinPhilInterPharma,Vietnam?CholinateHanMi,SouthKorea?CholineAlfoscerateElpen,Greece?CholitilineKukJe,SouthKorea?DelecitMDM,Italy?GlialfoYooYoung,SouthKorea?GliatilinDaeWoong,SouthKorea;Italfarmaco,Georgia;Italfarmaco,Italy;Italfarmaco,Poland;Italfarmaco,RussianFederation;Italfarmaco,Vietnam;ITF,Greece?GreiaKoreaPrimePharm,SouthKorea?NoebraMeditrina,GreeceCholinealfoscerate(alsoknownasAlpha-GPC)isL-a-glycerylphosphorylcholine(GPC),akeybraincellmembranephospholipidandcholinergicprecursor.Itisasourceofcholineforthesynthesisoftheneurotransmitteracetylcholine,withagreaterabilitytopenetratetheblood-brainbarrierthanconventionalcholinesources.Moreimportantly,Cholinealfosceratehasbeenexperimentallydemonstratedtoreduceorreverseage-relatedstructuralchangesinthefrontalcortexandhippocampusandinducedfunctionaldeficienciesofthecholinergicsystem.Researchsupportscholinealfoscerate'sabilitytosupporthealthybrainfunctionandthereleaseofsomatotrophin(hGH).Whilecomplexmentalprocesslikememoryandattentioncannotbereducedtoasingle,simplechemicalpathway,itisundeniablethatthefunctionofthecholinergicsystemofthebrain-thoseaspectsofbrainfunctioninvolvinganeurotransmitter(brainmessenger-molecule)calledacetylcholine(ACh)-iscentraltoourmentalfunction,andespeciallyourabilitytofocusandtorememberfactsandverbalinformation.AcetylcholineismadeinthenervoussystemfromaB-vitamin-likerawmaterialcalledcholine.Whenapersonisyoung,themorecholineheorshetakesinfromdietandsupplements,themoreAChgetsmade,thebetterhisorhermemorybecomes.Asweage,thatstrategybecomeslessandlesseffective,becausethestructureandfunctionofthecholinergicsystemitselfsuffersaslow,insidiousdecline.Theagingbrain'scholinergicfunctionisimpairedatseveralpoints,allofwhichaffectmentalperformance:?Theabilityofthebraintotakeinnecessaryrawmaterials.?Thelossofbalanceinkeycholinergicenzymes.?Thelossofchoinergicneurons.Cholinealfoscerate(al-FOSS-er-ate),oralpha-glycerylphosphorylcholine(GPC),isaphospholipid-acomplexfattysubstancecontainingphosphorus,likephosphatidylserineandphosphatidylcholine-andisanimportantbuildingblockintheconstructionofnervecellmembranes.Aftercompletingananalysisofthirteenpublishedclinicaltrials,involvingover4000patients,agroupofItalianscientistsconcludedthat\statedtherapeuticusefulnessofCholineAlfoscerateinthereliefofcognitivesymptoms,suchasmemoryandattentionimpairment,differentiates[it]fromcholinergicprecursorsusedinformerclinicaltrials\suchascholine,lecithin,orphosphatidylcholine.Thereason,asevidencenowsuggests,isthattheeffectsofthisversatilenutrientextendwellbeyonditsroleasamerecholinesource:cholinealfosceratesupportstherestorationofawholespectrumofyouthfulcholinergicfunctions.