有机立体化学-Slid-8

PCO2MeMeRh / L*+H2ArNHBz

PhOPPhPButOPh 82% ee 92% eeFiaud (1999)Pringle (2000)

新型手性螺环单磷配体

Ar*CO2MeNHBzup to 90% eeOPOOMe 95% eeReetz (2000)MeOCAMPKnowles (JCS CC 1972, 10)

OPNMeO2 95% eeFeringa (2000)50

OPhOMe+H2NHAcNOPOSIPHOS-Me 99% eeOPNOMonoPhos 98% eeRh(COD)2BF4 / L*1 atm / Toluene / 0oCOPhOPO ShiP99% eeOPOPhO71% eeOPhOMeNHAcPhOPO FuP 91% eeOPPhO63% ee51

碳－氧双键氢化

例一

OPhONHCHH2 / RhL*OH2PhPhONHCH2PhHClHCl97% ee (100% Y)L* =(C6H11)2PPPh2NCONHCH3

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例二

OOOC2H5例三

OOClOC2H5

/ Ru(R-BINAP)OHOH2 OC2H599% ee H2 / Ru(S-BINAP)OHOClOC2H5OHMe3N+CO2-

肉毒碱

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