年产500吨盐酸二甲双胍的工艺工段设计

华北科技学院毕业设计

ohexanol.Continue to heat to the reaction temperature, the intense exothermic reaction after the start, the reaction kettle inside dish tube into the cooling water for cooling, control reaction temperature at 145 ℃ ~ 150 ℃.Crystal slurry into the centrifuge to jilt, using anhydrous ethanol washing, dry.Coarse product metformin hydrochloride into the jacket insulation bag filter (decoloring cans), add 70% ethanol aqueous solution heat until completely dissolved, add activated carbon, reflow heat preservation decoloring 15-25 min, and then keep 75-82 ℃, pressure filtrate all into the crystallizing tank.Into the open circulating water cooling crystallization cans, must carry on the control cooling, the cooling process every 10 minutes to reduce 1 ℃, and variable frequency control speed between 20 to 35 r/min, cooled to below 10 ℃, centrifugal, into the recycling process from the mother liquor.Solid with anhydrous ethanol to wash raw materials.The material into the dryer, dry, for a quick finished metformin hydrochloride. The above process can be broadly divided into two phases, stages of rough and refined.The refined phase is divided into decolorizing, refining crystallization, drying, a few. 2.1.2 crude stage

Material and solvent, respectively, to join in the reaction kettle heating dissolving reaction and controlled cooling discharge plasma 2.1.3 refining stage

2.1.3.1 centrifugal dry mother liquor into the reaction kettle to recycle Crystal slurry into the centrifuge to dry Dry materials into the decoloring cans 2.1.3.2 decoloring process

Dry materials into the decoloring 70% aqueous can join soluble after joining pressure

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年产500吨盐酸二甲双胍的工艺工段设计

backflow insulation decolorizing activated carbon filtering crystallization mother liquor into the pot

The waste carbon

2.1.3.3 refined crystallization

Mother liquor into the crystallizing tank slowly cooling crystallization crystal plasma discharge

2.3.4 centrifugal dry

Dry material of anhydrous ethanol washing centrifugal dry dry Crystal slurry into the centrifuge for dry Mother liquor into the decoloring cans recycled 2.1.3.4 dry

Dry wet goods into the dryer 2.2 design structure 2.2.1 design calculation

In design and calculation, the main materials for the whole process, the energy balance argument and related equipment selection calculation. Equipment selection results as follows:

Centrifuge model SS - 1000 centrifuge with three legs Decolorizing tank model H - 24 p2s jacket insulation bag filter Drying machine, vibration fluidized bed dryer 2.2.2 design specification

Notes in the design, is mainly composed of five most content: general design, process

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华北科技学院毕业设计

the results summary, main process equipment operation index, plant layout, discussion and other.

The meaning of general part, the paper introduces the design and the determination of production plan and process flow.

Listed in the second part, the crystallization process of material, energy balance and the results and the result of the equipment type selection.

The third part, lists the crystallization reaction kettle, centrifuge, filter machine, drying machine main operation index.

The fourth part introduces the plant layout.

The fifth part discusses the security technology and energy saving, investment and cost estimation and related problems.

Keyword：Metformin hydrochloride；dicyandiamide；cyclohexanol；The crystallization；The production process

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