监测血糖波动减少糖尿病血管并发症 - 图文

基础研究的证据

湖南天泰

间断性高葡萄糖浓度对体外培养细胞的影响湖南天泰

2.52.521.510.50Day 1Day 2Day 3Day 4Day 1Day 2Day 3Day 4高糖21.5低糖10.50高糖和低糖交替

Risso A, et al. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. Am J Physiol Endocrinol Metab 2001; 281: E924-E930.

湖南天泰

正常葡萄糖间断性高葡萄糖

高葡萄糖

?体外培养人脐静脉内皮

细胞14天后，间断性高葡萄糖环境下细胞凋亡明显

Risso A, et al. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture. Am J Physiol Endocrinol Metab 2001; 281: E924-E930.

结论：

血糖波动的毒性作用大于稳定的高血糖状态湖南天泰

细胞碘化丙啶染色阳性率％7天和14天不同葡萄糖浓度下人脐静脉内皮细胞的调亡

Risso A, et al. Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in

culture. Am J Physiol Endocrinol Metab 2001; 281: E924-E930.