细胞生物学研究中的激活剂和抑制剂

mechanism that does not involve direct activation of protein kinase C. Diabetes. 1998;47:1722-6 PMID

9792541

Hansen A, Hansen J, Carr R, Ashcroft F, Wahl P. Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels. Br J Pharmacol. 2005;144:551-7 PMID 15678092

Sheng F, Ren X, Dai X, Xu X, Dong M, Pei Q, et al. Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:958-63 PMID 22086006 CrossRef

Kühner P, Prager R, Stephan D, Russ U, Winkler M, Ortiz D, et al. Importance of the Kir6.2 N-terminus for the interaction of glibenclamide and repaglinide with the pancreatic K(ATP) channel. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:299-311 PMID 22083559 CrossRef

Dabrowski M, Wahl P, Holmes W, Ashcroft F. Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels. Diabetologia. 2001;44:747-56 PMID 11440368 Diaz-Guerra M, Junco M, Bosca L. Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes. J Biol Chem. 1991;266:23568-76 PMID 1748635

Norikura T, Mukai Y, Fujita S, Mikame K, Funaoka M, Sato S. Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells. Basic Clin Pharmacol Toxicol. 2010;107:813-7 PMID 20412465

CrossRef

Kofod H. Secretin and the endocrine pancreas. Structure-activity relationship between secretin and the release of glucose-regulated hormones from isolated pancreatic islets. Acta Endocrinol (Copenh). 1992;126:1-41 PMID 1734624

Kofod H, Hansen B, Lernmark A, Hedeskov C. Secretin and its C-terminal hexapeptide potentiates insulin release in mouse islets. Am J Physiol. 1986;250:E107-13 PMID 3513606

Wang J, Novak I. Ion transport in human pancreatic duct epithelium, Capan-1 cells, is regulated by secretin, VIP, acetylcholine, and purinergic receptors. Pancreas. 2013;42:452-60 PMID 22982819 CrossRef Wang L, Rothberg K, Anderson R. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol. 1993;123:1107-17 PMID 8245121

Vercauteren D, Vandenbroucke R, Jones A, Rejman J, Demeester J, De Smedt S, et al. The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. Mol Ther. 2010;18:561-9

PMID 20010917 CrossRef

Wu M, Yuan F. Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. PLoS ONE. 2011;6:e20923 PMID 21695134 CrossRef

Rejman J, Bragonzi A, Conese M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Mol Ther. 2005;12:468-74 PMID 15963763

Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem. 1987;262:5592-5 PMID 3106339

Nabi I, Le P. Caveolae/raft-dependent endocytosis. J Cell Biol. 2003;161:673-7 PMID 12771123

Buschiazzo J, Bonini I, Alonso T. Inhibition of Bufo arenarum oocyte maturation induced by cholesterol depletion by methyl-beta-cyclodextrin. Role of low-density caveolae-like membranes. Biochim Biophys Acta. 2008;1778:1398-406 PMID 18395513 CrossRef

Koivusalo M, Welch C, Hayashi H, Scott C, Kim M, Alexander T, et al. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol. 2010;188:547-63

PMID 20156964 CrossRef

Kleyman T, Cragoe E. Amiloride and its analogs as tools in the study of ion transport. J Membr Biol. 1988;105:1-21 PMID 2852254

Alliegro M, Alliegro M, Cragoe E, Glaser B. Amiloride inhibition of angiogenesis in vitro. J Exp Zool. 1993;267:245-52 PMID 7693860

Wang Y, Yang Y, Liu X, Wang N, Cao H, Lu Y, et al. Inhibition of clathrin/dynamin-dependent

internalization interferes with LPS-mediated TRAM-TRIF-dependent signaling pathway. Cell Immunol. 2012;274:121-9 PMID 22341560 CrossRef

Varkevisser R, Houtman M, Waasdorp M, Man J, Heukers R, Takanari H, et al. Inhibiting the

clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine. Pflugers Arch. 2013;465:247-59 PMID 23192368 CrossRef

Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10:839-50 PMID 16740485

Yue W, Yao S, Zhou X, Si Y, Sang H, Wang J, et al. [Inhibitory effect of caveolin-1 on endoplasmic reticulum stress-induced apoptosis in macrophages via p38 MAPK pathway]. Sheng Li Xue Bao. 2012;64:149-54 PMID 22513464

Orlandi P, Fishman P. Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. J Cell Biol. 1998;141:905-15 PMID 9585410

Schnitzer J, Oh P, Pinney E, Allard J. Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules. J Cell Biol. 1994;127:1217-32 PMID 7525606

Kim H, Gil S, Andrieux K, Nicolas V, Appel M, Chacun H, et al. Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells. Cell Mol Life Sci. 2007;64:356-64

PMID 17256088

Moriyama T, Marquez J, Wakatsuki T, Sorokin A. Caveolar endocytosis is critical for BK virus infection of

human renal proximal tubular epithelial cells. J Virol. 2007;81:8552-62 PMID 17553887

Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011;117:6392-403 PMID 21482707 CrossRef

Mellman I, Fuchs R, Helenius A. Acidification of the endocytic and exocytic pathways. Annu Rev Biochem. 1986;55:663-700 PMID 2874766

Mollenhauer H, Morre D, Rowe L. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim Biophys Acta. 1990;1031:225-46 PMID 2160275

Ippoliti R, Ginobbi P, Lendaro E, D'Agostino I, Ombres D, Benedetti P, et al. The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins. Cell Mol Life Sci. 1998;54:866-75 PMID

9760993

Pohlmann R, Kruger S, Hasilik A, Von Figura K. Effect of monensin on intracellular transport and receptor-mediated endocytosis of lysosomal enzymes. Biochem J. 1984;217:649-58 PMID 6231917 Jiang P, Zhao Y, Deng X, Mao Y, Shi W, Tang Q, et al. Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer. Biomed Pharmacother. 2010;64:609-14

PMID 20888174 CrossRef

Araki N, Johnson M, Swanson J. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J Cell Biol. 1996;135:1249-60 PMID 8947549 Sokolova V, Kozlova D, Knuschke T, Buer J, Westendorf A, Epple M. Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells. Acta Biomater. 2013;9:7527-35 PMID 23454056

CrossRef

Powis G, Bonjouklian R, Berggren M, Gallegos A, Abraham R, Ashendel C, et al. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994;54:2419-23 PMID 8162590 Liu Y, Shreder K, Gai W, Corral S, Ferris D, Rosenblum J. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem Biol. 2005;12:99-107 PMID

15664519

García-Pérez B, De la Cruz-López J, Casta?eda-Sánchez J, Mu?óz-Duarte A, Hernández-Pérez A, Villegas-Castrejon H, et al. Macropinocytosis is responsible for the uptake of pathogenic and

non-pathogenic mycobacteria by B lymphocytes (Raji cells). BMC Microbiol. 2012;12:246 PMID 23113903

CrossRef

Lunov O, Syrovets T, Loos C, Beil J, Delacher M, Tron K, et al. Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line. ACS Nano. 2011;5:1657-69

PMID 21344890 CrossRef

Emerit I, Cerutti P. Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action. Nature. 1981;293:144-6 PMID 7266668

Sandvig K, van Deurs B. Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis. J Biol Chem. 1990;265:6382-8 PMID 1969411

Johnson G, Dechtiaruk W, Solomon H. Gas-chromatographic determination of theophylline in human serum and saliva. Clin Chem. 1975;21:144-7 PMID 1116266

Fykerud T, Kjenseth A, Schink K, Sirnes S, Bruun J, Omori Y, et al. Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43. J Cell Sci. 2012;125:3966-76 PMID 22623726 CrossRef Takada Y, Hachiya M, Osawa Y, Hasegawa Y, Ando K, Kobayashi Y, et al.

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells. J Biol Chem. 1999;274:28286-92 PMID 10497185

Whitehurst A, Wilsbacher J, You Y, Luby-Phelps K, Moore M, Cobb M. ERK2 enters the nucleus by a carrier-independent mechanism. Proc Natl Acad Sci U S A. 2002;99:7496-501 PMID 12032311

Finlay D, Newmeyer D, Price T, Forbes D. Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores. J Cell Biol. 1987;104:189-200 PMID 3805121

Nagata Y, Burger M. Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding. J Biol Chem. 1974;249:3116-22 PMID 4830237

Yoshida M, Kudo N, Horinouchi S. [Leptomycin: a specific inhibitor of protein nuclear export]. Tanpakushitsu Kakusan Koso. 1999;44:1379-88 PMID 10412289

Buschbeck M, Ullrich A. The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling. J Biol Chem. 2005;280:2659-67 PMID 15548525

Reyes-Pardo H, Barbosa-Camacho A, Pérez-Mejía A, Lara-Chacón B, Salas-Estrada L, Robledo-Rivera A, et al. A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export. Biochim Biophys Acta. 2012;1823:1756-66 PMID 22796641 CrossRef

Wu W, Pante N. The directionality of the nuclear transport of the influenza A genome is driven by selective exposure of nuclear localization sequences on nucleoprotein. Virol J. 2009;6:68 PMID 19490630

CrossRef

Wolff B, Sanglier J, Wang Y. Leptomycin B is an inhibitor of nuclear export: inhibition of

nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997;4:139-47 PMID 9190288

Strunze S, Trotman L, Boucke K, Greber U. Nuclear targeting of adenovirus type 2 requires